RETN Gene Polymorphisms as Risk Factor in Diabetic Patients with Covid-19 Infection
Authors
Abstract:
People with diabetes mellitus (DM) represent a population group that is at high risk of developing a poor prognosis for COVID-19. Having diabetes increases the risk of serious illness, ICU stay, and death from COVID-19. The current study included 150 participants with diabetes, 100 patients of whom had COVID-19 (46 male, 54 female), and 50 had diabetes only (28 male, 22 female), aged between 37 and 69 years. Currently in the isolation center for people infected with the Corona virus and Shatrah General Hospital in Thi-Qar Governorate. The study included the impact of COVID-19 infection and its effect on pancreatic function. The results of the current study recorded a significant increase in random blood sugar concentration and HBA1C concentration in diabetic patients infected with Covid-19 virus compared to diabetic patients only. Regarding the molecular study of the gene encoding the protein resistin, the current study showed that diabetic patients with COVID-19 virus had a higher frequency of single nucleotide polymorphisms compared to diabetic patients only. X494T.C, X663A.C, X494T.C and X663A.C which recorded significant differences. While the following genetic mutations did not register a significant difference in the frequency of the following polymorphisms rs3219177, X542A.C, rs3745367.
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Journal title
volume 15 issue 1
pages 1001- 1013
publication date 2023-01
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